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List of substances for condition Group: Aging

All Human Animal Risk/Association ReviewRows: 732

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Curcumin 📋✍⛔38707049Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study
Melatonin 📋✍⛔38613097The Positive Association between Melatonin-Containing Food Consumption and Older Adult Life Satisfaction, Psychoemotional State, and Cognitive Function
Vitamin D3 📋✍⛔38599429Biophysical insight into the binding mechanism of epigallocatechin-3-gallate and cholecalciferol to albumin and its preventive effect against AGEs formation: An in vitro and in silico approach
Resveratrol 📋✍⛔38622329Resveratrol relieves HFD-induced insulin resistance in skeletal muscle tissue through antioxidant capacity enhancement and the Nrf2-Keap1 signaling pathway
Ginsenosides 📋✍⛔38669971Total ginsenosides extend healthspan of aging Drosophila by suppressing imbalances in intestinal stem cells and microbiota
Vitamin C 📋✍⛔38678062Association between vitamin C in serum and trouble sleeping based on NHANES 2017-2018
Quercetin 📋✍⛔38682342Effects of quercetin in preclinical models of Parkinson's disease: A systematic review
Astaxanthin 📋✍⛔38695248Astaxanthin attenuates UV-irradiation aging process via activating JNK-1/DAF-16 in Caenorhabditis elegans
Ginseng 📋✍⛔38707644Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia
EGCG 📋✍⛔38704088Bridging the gap: Integrating exercise mimicry into chronic disease management through suppressing chronic inflammation
Omega-3 Fatty Acids 📋✍⛔38718720Elevated tissue status of omega-3 fatty acids protects against age-related telomere attrition in fat-1 transgenic mice
Cannabidiol 📋✍⛔38590254Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis
Metformin 📋✍⛔38582410The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats
Vitamin E 📋✍⛔38296289Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Micronutrients 📋 ⛔38712453Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms
Ginkgo Biloba 📋✍⛔38654507Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease
Berberine 📋✍⛔38727934Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats
Sulforaphane 📋✍⛔37685936New Insight into the Potential Protective Function of Sulforaphene against ROS-Mediated Oxidative Stress Damage In Vitro and In Vivo
CoQ10 📋✍⛔38397789CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease
Genistein 📋✍⛔38275516Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease
Puerarin 📋✍⛔38554122FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption
Magnesium 📋✍⛔38693478Association between plasma metal exposure and health span in very elderly adults: a prospective cohort study with mixture statistical approach
Medicinal Plants 📋 38628649Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis
Selenium 📋✍⛔38707461Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack
Fisetin 📋✍⛔38278314Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6
Cocoa 📋✍⛔38674244Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study
Food 📋 38713264Diet to Stop Hypertension: Should Fats be Included?
NMN 📋✍⛔38445897β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice
Lipoic Acid 📋✍⛔38644711Alpha-lipoic Acid: An Antioxidant with Anti-Aging Properties for Disease Therapy
Lycopene 📋✍⛔37880898Lycopene Improves Bone Quality in SAMP6 Mice by Inhibiting Oxidative Stress, Cellular Senescence, and the SASP
Goji Berry 📋✍⛔38653878Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
Grape Seed extract 📋✍⛔37351191A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECISE study, a double-blind placebo-controlled cross-over intervention study
Blueberry 📋✍⛔38432561Intake of blueberries, anthocyanins, and risk of eye disease in women
Pomegranate 📋 ⛔38677577The power of Punica granatum: A natural remedy for oxidative stress and inflammation; a narrative review
Salidroside 📋 38424396Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson's Disease
Zinc 📋✍⛔38707461Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack
Astragalosides 📋✍⛔38412923Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation
Hesperidin 📋✍⛔38423185Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster
Luteolin 📋✍⛔38547625Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling
Rutin 📋✍⛔38723008Modulatory effects of rutin and vitamin A on hyperglycemia induced glycation, oxidative stress and inflammation in high-fat-fructose diet animal model
Apigenin 📋✍⛔38638133Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells
Moringa Oleifera 📋✍⛔37606026Evaluating the effectiveness of Moringa oleifera leaf capsules in controlling glycemic and hypertension levels in type 2 diabetes patients
Naringenin 📋✍⛔38308480Naringenin orchestrates and regulates the ROS-mediated pathways and proinflammatory signaling: targeting hallmarks of aging-associated disorders
N-Acetyl Cysteine 📋✍⛔38718763Ex vivo anti-senescence activity of N-acetylcysteine in visceral adipose tissue of obese volunteers
Vitamin B9 📋✍⛔38700503Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Ellagic Acid 📋✍⛔38201915Ellagic Acid Prevents α-Synuclein Spread and Mitigates Toxicity by Enhancing Autophagic Flux in an Animal Model of Parkinson's Disease
Crocin 📋✍⛔38469959Protective effect of crocin on peroxidation-induced oxidative stress and apoptosis in IPEC-J2 cells
Phytochemicals 📋 38471283Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease
Pine Bark 📋✍⛔38592434Pycnogenol® prevents skin hyperpigmentation following sclerotherapy
Walnut 📋 ⛔37372540Synergistic Effect of Combined Walnut Peptide and Ginseng Extracts on Memory Improvement in C57BL/6 Mice and Potential Mechanism Exploration
Saffron 📋✍⛔38485112Saffron therapy for the ongoing treatment of age-related macular degeneration
Lutein 📋✍⛔36986186Effects of Astaxanthin, Lutein, and Zeaxanthin on Eye-Hand Coordination and Smooth-Pursuit Eye Movement after Visual Display Terminal Operation in Healthy Subjects: A Randomized, Double-Blind Placebo-Controlled Intergroup Trial
Olive Oil 📋✍⛔38339193Extra-Virgin Olive Oil in Alzheimer's Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies
Senolytics 📋 38494091Senolytic therapeutics: An emerging treatment modality for osteoarthritis
Nicotinamide Riboside 📋✍⛔38676310Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene
Nigella Sativa 📋✍⛔38650731The efficacy and safety of Nigella sativa in the management of osteoarthritis: A systematic review
Baicalein 📋✍⛔38525128Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes
Docosahexaenoic Acid 📋✍⛔38373507N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma
Gotu Kola 📋✍⛔38381030Periostial and cartilage morphology in knee osteoarthritis: beneficial effects of supplementation with Pycnogenol® + Centellicum®
Icariin 📋✍ 38636375Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling
Frankincense 📋✍⛔38707049Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study
Naringin 📋✍⛔38312545Study on the mechanism of naringin in promoting bone differentiation: In vitro and in vivo study
Pterostilbene 📋✍⛔38676310Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene
Acetyl-L-Carnitine 📋✍⛔36988119A comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in AlCl3-induced Alzheimer's in rats
Anthocyanins 📋✍⛔37743923Gingerols synergize with anthocyanins to induce antioxidant activity in vitro
Green Tea Polyphenols 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Polyphenols 📋 38558823Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases
Schisandra 📋✍⛔38565361Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice
Ashwagandha 📋✍⛔38201986Ashwagandha Ethanol Extract Attenuates Sarcopenia-Related Muscle Atrophy in Aged Mice
Astragalus Root 📋✍⛔38675511The Antioxidant Action of Astragali radix: Its Active Components and Molecular Basis
Fucoidan 📋✍⛔37123974Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells
Whey Protein 📋✍⛔38612975Comparative Efficacy of Different Protein Supplements on Muscle Mass, Strength, and Physical Indices of Sarcopenia among Community-Dwelling, Hospitalized or Institutionalized Older Adults Undergoing Resistance Training: A Network Meta-Analysis of Randomized Controlled Trials
Chokeberry 📋✍⛔37049743Fermented Aronia melanocarpa Inhibits Melanogenesis through Dual Mechanisms of the PI3K/AKT/GSK-3β and PKA/CREB Pathways
Ginger 📋✍⛔38397589Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets
Spirulina 📋✍⛔37416477Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts
Reishi Mushrooms 📋✍⛔38720773Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease
Roselle 📋✍⛔38397511In Vivo Diuretic Activity and Anti-Hypertensive Potential of Hibiscus sabdariffa Extract by Inhibition of Angiotensin-Converting Enzyme and Hypertension Precursor Enzymes
Turmeric 📋✍⛔38212737Genus Curcuma: chemical and ethnopharmacological role in aging process
Vitamin B12 📋✍⛔38700503Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Chrysin 📋✍⛔38176443Chrysin alleviates DNA damage to improve disturbed immune homeostasis and pro-angiogenic environment in laser-induced choroidal neovascularization
Rapamycin 📋✍ 38640155Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies
Ferulic Acid 📋✍⛔38643459Ferulic acid in synergy with retinol alleviates oxidative injury of HaCaT cells during UVB-induced photoaging
Green Tea 📋✍⛔38706293Investigating the Impact of Tea Consumption on Cognitive Function and Exploring Tea-Genetic Interactions in Older Adults Aged 65-105 Years: Findings from the 2002-2018 CLHLS Data
Probiotics 📋✍⛔38510467Slowing Alzheimer's disease progression through probiotic supplementation
Carotenoids 📋✍⛔38219250Effect of carotenoid supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials
Grape 📋 ⛔37605542Impacts of regular consumption of grapes on macular pigment accumulation in Singapore older adults: a randomized controlled trial
Kaempferol 📋✍⛔38528143Network pharmacology analysis and experimental validation to explore the mechanism of kaempferol in the treatment of osteoporosis
Mulberry 📋 ⛔38612872Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays
Catechins 📋 38487922Restorative effects of (+)-epicatechin in a rodent model of aging induced muscle atrophy: underlying mechanisms
Hesperetin 📋 38517352Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids
NAD 📋 38340651The therapeutic perspective of NAD+ precursors in age-related diseases
Nobiletin 📋✍ 37598127The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism
Bee Propolis 📋✍⛔38583392Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Pomegranate Peel extract 📋✍⛔38726394Pistachio green hull and pomegranate peel extracts as two natural antiglycation agents
Thymoquinone 📋 ⛔38660812Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p
Gallic Acid 📋 ⛔38549642Gallic Acid Alleviates Cognitive Impairment by Promoting Neurogenesis via the GSK3β-Nrf2 Signaling Pathway in an APP/PS1 Mouse Model
Hawthorn 📋✍⛔38722076Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats
Hydroxytyrosol 📋 37834398The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease
Andrographolide 📋 38462021Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi-targets against osteoarthritis via network pharmacological analysis and experimental validation
Antioxidants 📋 ⛔38612608Research Progress on Bioactive Factors against Skin Aging
Carvacrol 📋✍⛔38649135Neuroprotective role of Carvacrol via Nrf2/HO-1/NLRP3 axis in Rotenone-induced PD mice model
Fish Oil 📋✍⛔38348197Fish oil supplementation, physical activity and risk of incident Parkinson's disease: results of longitudinal analysis from the UK Biobank
Coconut Oil 📋 ⛔38106629Assessment of the neuroprotective effect of Cocos nucifera L. oil on learning and behavior impairment in ovariectomized rats
Caffeine 📋✍⛔38513162Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort
Cinnamon 📋✍⛔37655003Hepatic regenerative response to long-term consumption of cinnamon-rich diet in aged rats
Glucosamine 📋✍⛔38732122Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells
Zeaxanthin 📋✍⛔37430077Prevention Surpasses Treatment: 5-year Follow-Up, Cost-Utility, and Cost-Benefit of Zeaxanthin Therapy for Neovascular Age-Related Macular Degeneration
Angelica 📋✍⛔37632225Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways
Flavonoids 📋 ⛔38398799Effect of Polyphenol Supplementation on Memory Functioning in Overweight and Obese Adults: A Systematic Review and Meta-Analysis
Mangiferin 📋 ⛔38176266Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway
Soy 📋✍⛔38474777Royal Jelly and Fermented Soy Extracts-A Holistic Approach to Menopausal Symptoms That Increase the Quality of Life in Pre- and Post-menopausal Women: An Observational Study
Boswellic Acid 📋✍⛔37248896Boswellic Acids Improve Clinical Cognitive Scores and Reduce Systemic Inflammation in Patients with Mild to Moderate Alzheimer's Disease
Ginkgolides 📋 38676673[Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease]
L-Arginine 📋✍⛔38004100Arginine and Lysine Supplementation Potentiates the Beneficial β-Hydroxy ß-Methyl Butyrate (HMB) Effects on Skeletal Muscle in a Rat Model of Diabetes
Oleuropein 📋 37049607Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota
Silibinin 📋✍ 38732122Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells
TUDCA 📋✍⛔38665027Tauroursodeoxycholic Acid Mitigates Oxidative Stress and Promotes Differentiation in High Salt-Stimulated Osteoblasts via NOX1 Mediated by PGC-1α
Baicalin 📋✍⛔38377551Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1
Coffee 📋✍⛔38714417Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities
Collagen 📋✍ 38612608Research Progress on Bioactive Factors against Skin Aging
Ollive Leaf extract 📋✍⛔38306771Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity
Polypodium Leucotomos 📋✍⛔36358556Protective Effect of the Hydrophilic Extract of Polypodium leucotomos, Fernblock®, against the Synergistic Action of UVA Radiation and Benzo[a]pyrene Pollutant
Rosmarinic Acid 📋✍ 38529831The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity
Chondroitin 📋✍⛔38707049Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study
Licorice Root 📋✍⛔35307886Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)-mediated neuroprotection in a rotenone-induced cellular model of Parkinson's disease by restoring the mTORC1-AMPK1 axis in autophagic regulation
Sea Buckthorn 📋✍⛔38370085Anti-skin aging effect of sea buckthorn proanthocyanidins in D-galactose-induced aging mice
Allicin 📋✍⛔36557926Allicin Alleviates Diabetes Mellitus by Inhibiting the Formation of Advanced Glycation End Products
Cherry 📋 ⛔37371879Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats
Dihydromyricetin 📋✍⛔38500495Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin
Fucoxanthin 📋✍⛔36978877The Role of Fucoxanthin as a Potent Nrf2 Activator via Akt/GSK-3β/Fyn Axis against Amyloid-β Peptide-Induced Oxidative Damage
Silymarin 📋✍⛔38353101Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease
Strawberry 📋✍⛔35766389Impact of different processing methods on the phenolics and neuroprotective activity of Fragaria ananassa Duch. extracts in a D-galactose and aluminum chloride-induced rat model of aging
Aged Garlic 📋✍⛔37686723Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
Beets 📋✍⛔38572540Nitrate ingestion blunts the increase in blood pressure during cool air exposure. A double-blind, placebo-controlled, randomized, crossover trial
DHEA 📋✍⛔36982376DHEA and Its Metabolites Reduce the Cytokines Involved in the Inflammatory Response and Fibrosis in Primary Biliary Cholangitis
Fenugreek 📋✍⛔37484294Fenugreek seed ethanolic extract inhibited formation of advanced glycation end products via scavenging reactive carbonyl intermediates
Lavender Essential Oil 📋✍⛔38490827The effect of lavender and bergamot oil applied via inhalation on the anxiety level and sleep quality of surgical intensive care unit patients
Orange 📋 ⛔37469434Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers
Piperine 📋✍⛔38158101Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats
Tea 📋 38714417Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities
L-Carnitine 📋✍⛔38389158Effect of l-Carnitine Supplementation on Osteoarthritis: A Systematic Review
L-Leucine 📋✍⛔37898392Dietary leucine supplementation restores T-cell mitochondrial respiration and regulates T-lineage differentiation in denervation-induced sarcopenic mice
Urolithins 📋 38465899Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation
HMB 📋✍⛔38598977Relationship of endogenous plasma concentrations of β-hydroxy β-methyl butyrate (HMB) with frailty in community dwelling older adults with type-2 diabetes mellitus
Plum 📋 ⛔38375074Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice
PQQ 📋✍⛔38487591Dietary pyrroloquinoline quinone hinders aging progression in male mice and D-galactose-induced cells
Vitamin K2 📋✍⛔36033779Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials
Vitamin K2 mk-7 📋✍ 37477796Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
Apple 📋 ⛔35502671"An apple a day keeps the doctor away": The potentials of apple bioactive constituents for chronic disease prevention
BCAA 📋✍⛔37686735The Role of Nutrition in the Treatment of Sarcopenia in Old Patients: From Restoration of Mitochondrial Activity to Improvement of Muscle Performance, a Systematic Review
Hyaluronic Acid 📋✍⛔38707049Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study
L-Citrulline 📋✍⛔38338891Perinatal Use of Citrulline Rescues Hypertension in Adult Male Offspring Born to Pregnant Uremic Rats
Nicotinamide 📋✍⛔38671873Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products
Punicalagin 📋✍⛔37896179Punicalagin's Protective Effects on Parkinson's Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway
Taurine 📋✍⛔38548872Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2
Acai Berry 📋✍⛔37107223Aging Injury Impairs Structural Properties and Cell Signaling in Human Red Blood Cells; Açaì Berry Is a Keystone
Black Tea 📋✍⛔37628133Effects of Key Components on the Antioxidant Activity of Black Tea
Dandelion 📋✍⛔37685246Dandelion ( Taraxacum mongolicum) Extract Alleviated H2O2-Induced Oxidative Damage: The Underlying Mechanism Revealed by Metabolomics and Lipidomics
Galangin 📋 37689035Pharmacological activities and therapeutic potential of galangin, a promising natural flavone, in age-related diseases
Lotus 📋 ⛔38449662Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome
Protein 📋✍⛔38732628Protein Intake and Physical Activity Levels as Determinants of Sarcopenia Risk in Community-Dwelling Older Adults
Asiatic Acid 📋 37580921Asiatic acid ameliorates life and health span in fruit fly
Eicosapentaenoic Acid 📋✍⛔38373507N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma
L-Theanine 📋✍⛔37919877L-Theanine delays D-galactose-induced senescence by regulating the cell cycle and inhibiting apoptosis in rat intestinal cells
Olive Polyphenols 📋 36364796Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties
Stinging Nettle 📋✍⛔38387425The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats
Vitamin K 📋✍⛔37525012Vitamin K insufficiency predicts incidence of frailty in community-dwelling older adults: The Otassha Study
Chlorogenic Acid 📋✍⛔38461437Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation
Cinnamaldehyde 📋 38621979[Improvement effect of cinnamaldehyde on reserpine-induced Parkinson's disease rat model]
Indian Gooseberry 📋 ⛔38030098Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats
Kudzu Root 📋✍⛔38312605A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways
Skullcap 📋✍⛔38645989Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease
Argan Oil 📋✍⛔38539877The Potential Role of Major Argan Oil Compounds as Nrf2 Regulators and Their Antioxidant Effects
Beta-Carotene 📋✍⛔38019728Diet-derived antioxidants and osteoporosis: A Mendelian randomization study
Citicoline 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Diosmin 📋✍⛔36903535Diosmin and Bromelain Stimulate Glutathione and Total Thiols Production in Red Blood Cells
Eugenol 📋 38444813Protective role of Eugenol against the destructive effects of lead on conditioned fear memory in male rats with post-traumatic stress disorder-related behavioral traits
Garlic 📋✍⛔36945935Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures
Gingerol 📋✍ 38397589Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets
Rosemary 📋✍⛔38470170Rosemary extract and rosmarinic acid accelerate elastic fiber formation by increasing the expression of elastic fiber components in dermal fibroblasts
Almond 📋 ⛔36842635Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials
Eucommia 📋✍⛔37212195Asperuloside, the bioactive compound in the edible Eucommia ulmoides male flower, delays muscle aging by daf-16 mediated improvement in mitochondrial dysfunction
Kacip Fatimah 📋✍⛔37219787Marantodes pumilum (Kacip Fatimah) Aqueous Extract Enhances Osteoblast and Suppresses Osteoclast Activities in Cancellous Bone of a Rat Model of Postmenopause
Lemon Balm 📋✍⛔36502333Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial
Paeoniflorin 📋 38226230MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo
Persimmon 📋 ⛔38674937Osteogenic Effects of the Diospyros lotus L. Leaf Extract on MC3T3-E1 Pre-Osteoblasts and Ovariectomized Mice via BMP2/4 and TGF β Pathways
Soy Isoflavones 📋✍⛔38674244Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study
Trehalose 📋 ⛔37869632Trehalose delays postmenopausal osteoporosis by enhancing AKT/TFEB pathway‑dependent autophagy flow in rats
Vitamin B6 📋✍⛔38432716Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
Caffeic Acid 📋✍⛔38636398Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway
Calcium 📋✍⛔38366270Effects of vitamin D and/or calcium intervention on sleep quality in individuals with prediabetes: a post hoc analysis of a randomized controlled trial
Chlorella 📋✍⛔37144207Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease
Cranberry 📋✍⛔38626462A polyphenol-rich cranberry supplement improves muscle oxidative capacity in healthy adults
Date 📋 ⛔38565410Anti-inflammatory and anti-rheumatic effects of Phoenix dactylifera L. (date palm) seed by controlling cytokines and inhibiting JAK1/STAT3 pathway on CFA-induced arthritis rat and its phytochemical profiling
Folate 📋✍⛔37735121Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis
L-Carnosine 📋✍⛔38243982The Possible Roles of β-alanine and L-carnosine in Anti-aging
Raspberry 📋✍⛔38628181The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta-analysis
Sage 📋✍⛔37489230The Effect of Salvia Officinalis on Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis
Dihydroquercetin 📋 38723817Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation
Peony 📋 ⛔38649260Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis
Spermidine 📋 38401586Synergistic effect of spermidine and ciprofloxacin against Alzheimer's disease in male rat via ferroptosis modulation
Wormwood 📋✍⛔37331451Effects of Artemisia annua L. on postmenopausal syndrome in ovariectomized mice
Aloe Vera 📋✍⛔36243792Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis
Geniposide 📋 38468352Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway
Glycyrrhizic Acid 📋✍⛔38725079Glycyrrhizic acid inhibits DNA damage repair and enhances cisplatin-induced apoptosis of melanoma cells
Lion's Mane Mushrooms 📋✍⛔38248449Hericium erinaceus Extract Exerts Beneficial Effects on Gut-Neuroinflammaging-Cognitive Axis in Elderly Mice
Tangeretin 📋 36846469Characterization of tangeretin as an activator of nuclear factor erythroid 2-related factor 2/antioxidant response element pathway in HEK293T cells
Tribulus Terrestris 📋✍⛔35345408Eucommia ulmoides Oliver- Tribulus terrestris L. Drug Pair Regulates Ferroptosis by Mediating the Neurovascular-Related Ligand-Receptor Interaction Pathway- A Potential Drug Pair for Treatment Hypertension and Prevention Ischemic Stroke
Vitamin A 📋✍⛔38723008Modulatory effects of rutin and vitamin A on hyperglycemia induced glycation, oxidative stress and inflammation in high-fat-fructose diet animal model
Vitamin B3 📋✍⛔38627220Niacin supplementation attenuates the regression of three-dimensional capillary architecture in unloaded female rat skeletal muscle
Avocado 📋✍⛔35979778Avocado consumption is associated with a reduction in hypertension incidence in Mexican women
Black Pepper 📋✍⛔37237954Black Pepper ( Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent against Neurodegenerative Diseases
Creatine 📋✍⛔38684784Comparing the efficacy of concomitant treatment of resistance exercise and creatine monohydrate versus multiple individual therapies in age related sarcopenia
Graviola 📋✍⛔36678273The Antioxidant Potential of Graviola and Its Potential Medicinal Application
Irisin 📋 38672282Irisin and Its Role in Postmenopausal Osteoporosis and Sarcopenia
Mangosteen 📋✍⛔36552604Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease
Myricetin 📋 ⛔38423257Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats
Valerian Root 📋✍⛔37899385Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study
Vitamin K2 mk-4 📋✍ 34444729Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling
Vitamins 📋 38588735Effect modification of diet and vitamins on the association between air pollution particles of different diameters and hypertension: A 12-year longitudinal cohort study in densely populated areas of China
Asiaticoside 📋 38597444[Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats]
Beta-Cryptoxanthin 📋 33540706Effects of β-Cryptoxanthin on Improvement in Osteoporosis Risk: A Systematic Review and Meta-Analysis of Observational Studies
Capsaicin 📋✍⛔37995921Capsaicin inhibits A7r5 cell senescence via the mitochondrial carrier protein Slc25a12
Chrysanthemum 📋✍⛔36986039Chrysanthemum morifolium and Its Bioactive Substance Enhanced the Sleep Quality in Rodent Models via Cl- Channel Activation
Krill Oil 📋✍⛔37888448Anti-Osteoarthritic Effects of Antarctic Krill Oil in Primary Chondrocytes and a Surgical Rat Model of Knee Osteoarthritis
Procyanidins 📋 ⛔38366688Cacao Procyanidins-Induced Lifespan Extension in Caenorhabditis elegans in a Nervous System and CaMKII Dependent Manner
Carnosic Acid 📋 36224322Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells
Crocetin 📋 38097101Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models
Elderberry 📋✍⛔36211754Elderberry ( Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity
Emodin 📋 ⛔38570055Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study
Essential Oils 📋 ⛔38397967Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data
Fish Collagen 📋✍⛔38667776Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging
Fruits 📋 38347678Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study
Ginger extract 📋✍⛔36837393Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study
Kiwifruit 📋✍⛔37242157The Impact of Kiwifruit Consumption on the Sleep and Recovery of Elite Athletes
Onion 📋✍⛔38688382Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Prebiotics 📋✍⛔38495755Gut microbiota and its metabolites in Alzheimer's disease: from pathogenesis to treatment
Red Sage 📋✍⛔38281062Efficacy of a mixed extract of Salvia miltiorrhiza and Paeonia lactiflora in inhibiting the aging of vascular wall through in vitro and in vivo experiments
Salvianolic Acid 📋 38565040Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway
St. Johns Wort 📋✍⛔38279301Apolar Extracts of St. John's Wort Alleviate the Effects of β-Amyloid Toxicity in Early Alzheimer's Disease
Theaflavins 📋✍ 36718846Theaflavins in Black Tea Mitigate Aging-Associated Cognitive Dysfunction via the Microbiota-Gut-Brain Axis
Tongkat Ali 📋✍⛔37968729Eurycoma longifolia (Tongkat Ali) enhances wakefulness during active periods but facilitates sleep during resting periods in C57BL/6 mice
Wogonin 📋✍⛔38154963Wogonin attenuates vascular remodeling by inhibiting smooth muscle cell proliferation and migration in hypertensive rat
Arctigenin 📋 38104254Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism
Betaine 📋✍⛔38488483Betaine postpones hyperglycemia-related senescence in ovarian and testicular cells: Involvement of RAGE and β-galactosidase
Bilberry 📋✍⛔37351191A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECISE study, a double-blind placebo-controlled cross-over intervention study
Cat's Claw 📋✍⛔35260150GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome
Chamomile 📋✍⛔38226236A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile
Choline 📋✍⛔38334759Effect of Dietary Choline Consumption on the Development of Urinary Urgency Incontinence in a Longitudinal Cohort of Women
Coconut 📋 ⛔36656985Coconut Sugar Derived from Coconut Inflorescence Sap Lowers Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults: A Pilot Study
Echinacea 📋✍⛔38459283Echinacea purpurea root extract mitigates hepatotoxicity, genotoxicity, and ultrastructural changes induced by hexavalent chromium via oxidative stress suppression
Haritaki 📋✍⛔36940283Reduction of Senescence Associated Secretory Phenotype and exosome-shuttled miRNAs by Haritaki fruit extract in senescent dermal fibroblasts
Spikenard 📋✍⛔37559448Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways
Telmisartan 📋 ⛔38419447Telmisartan Protects Mitochondrial Function, Gait, and Neuronal Apoptosis by Activating the Akt/GSK3β/PGC1α Pathway in an MPTP-Induced Mouse Model of Parkinson's Disease
Basil 📋✍⛔37154241Effects of Ocimum basilicum L. Extract on Hippocampal Oxidative Stress, Inflammation, and BDNF Expression in Amnesic Aged Rats
Black Cohosh 📋✍⛔37192826Black cohosh extracts in women with menopausal symptoms: an updated pairwise meta-analysis
Coriander 📋 ⛔36362997Evaluation of the Cardiovascular Effects of Coriandrum sativum and Citrus limon to Treat Arsenic-Induced Endothelial Damage and Hypertension in Rats
Daidzein 📋✍⛔38679467Daidzein ameliorates nonmotor symptoms of manganese-induced Parkinsonism in zebrafish model: Behavioural and biochemical approach
Evening Primrose Oil 📋✍⛔37694196Comparison of the Effect of Fennel and Evening Primrose Oil on Menopausal Problems and Hormonal Levels: A Randomized Controlled Trial
Fish 📋 ⛔38706279Fish and Shellfish Consumption, Cognitive Health and Mortality from Alzheimer's Disease among US Adults Aged 60 and Older
Ganoderic Acid 📋 37984927Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway
Hyperoside 📋 38722076Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats
Ligustilide 📋 38183407Ligustilide, A Novel Senolytic Compound Isolated from the Roots of Angelica Acutiloba
Thyme 📋✍⛔38039009Effects of orally administered Thymus vulgaris leaves on memory, anxiety, depression, and sleep quality in university students: a randomized controlled trial
5-HTP 📋✍⛔38309227The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Acacetin 📋 36520340Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose
Bergamot 📋✍⛔38242036The protective effect of Bergamot Polyphenolic Fraction on reno-cardiac damage induced by DOCA-salt and unilateral renal artery ligation in rats
Blackberry 📋 ⛔38430352Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling
Blackcurrant 📋✍⛔37893207Blackcurrant Anthocyanins Improve Blood Lipids and Biomarkers of Inflammation and Oxidative Stress in Healthy Women in Menopause Transition without Changing Body Composition
Burdock 📋 ⛔33086080Dicaffeoylquinic acids alleviate memory loss via reduction of oxidative stress in stress-hormone-induced depressive mice
Calycosin 📋 38254101Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism
Cardamom 📋✍⛔38268891Effect of cardamom consumption on inflammation and blood pressure in adults: A systematic review and meta-analysis of randomized clinical trials
Cordycepin 📋 38479634Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation
Cordyceps 📋✍⛔38673866NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity
Echinacoside 📋 38000105Echinacoside exerts neuroprotection via suppressing microglial α-synuclein/TLR2/NF-κB/NLRP3 axis in parkinsonian models
Essential Amino Acids 📋✍⛔36720768Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
Fiber 📋✍⛔38586958Recommendations for the Use of Dietary Fiber to Improve Blood Pressure Control
Fig 📋 ⛔37416794AGEs Blockerâ„¢ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice
Fo-Ti Root 📋✍⛔38103673Anti-aging activities of neutral and acidic polysaccharides from Polygonum multiflorum Thunb in Caenorhabditis elegans
GABA 📋✍⛔38321713GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial
Galangal 📋✍⛔36306920Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression
Glycine 📋✍⛔37960231Glycine and N-Acetylcysteine (GlyNAC) Combined with Body Weight Support Treadmill Training Improved Spinal Cord and Skeletal Muscle Structure and Function in Rats with Spinal Cord Injury
Nuts 📋 ⛔37950985Higher lacto-vegetarian dietary score is associated with reduced risk of postmenopausal osteoporosis: A case-control study in a sample of Iranian postmenopausal women
PUFA 📋 38612907Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review
Schisandrins 📋 38285126Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells
Tanshinone 📋 38659601Tanshinone IIA improves Alzheimer's disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis
Tea Polyphenols 📋 38307369Study on the relationship between tea polyphenols alleviating osteoporosis and the changes of microorganism-metabolite-intestinal barrier
Tetrahydrocurcumin 📋✍ 36971089Tetrahydrocurcumin Add-On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury
Thymol 📋✍⛔36808768Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model
Ursolic Acid 📋✍⛔37841938Anti-inflammatory and antioxidant activity of ursolic acid: a systematic review and meta-analysis
White Tea 📋 ⛔34369381Effect of white tea consumption on serum leptin, TNF-α and UCP1 gene expression in ovariectomized rats
Alpha-Linolenic Acid 📋✍⛔37105373Long-term dietary n3 fatty acid prevents aging-related cardiac diastolic and vascular dysfunction
Aspirin 📋 ⛔38039031Comprehensive systematic review and meta-analysis on anticoagulants and aspirin for stroke prevention in non-valvular atrial fibrillation patients
Barberry 📋✍⛔36408260Berbamine inhibits RANKL- and M-CSF-mediated osteoclastogenesis and alleviates ovariectomy-induced bone loss
Brazil Nut 📋 ⛔38575248Brazil nut consumption reduces DNA damage in overweight type 2 diabetes mellitus patients
Bromelain 📋✍⛔36903535Diosmin and Bromelain Stimulate Glutathione and Total Thiols Production in Red Blood Cells
Catalpol 📋 38100921Catalpol attenuates osteoporosis in ovariectomized rats through promoting osteoclast apoptosis via the Sirt6-ERα-FasL axis
Diosmetin 📋 36563736Diosmetin inhibits subchondral bone loss and indirectly protects cartilage in a surgically-induced osteoarthritis mouse model
Fennel 📋✍⛔37694196Comparison of the Effect of Fennel and Evening Primrose Oil on Menopausal Problems and Hormonal Levels: A Randomized Controlled Trial
Formononetin 📋 36306560Formononetin inhibits IL-1β-induced inflammation in human chondrocytes and slows the progression of osteoarthritis in rat model via the regulation of PTEN/AKT/NF-κB pathway
Isoflavones 📋✍⛔37875614Isoflavone intervention and its impact on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
Lactobacillus plantarum 📋 ⛔38575308Lactobacillus plantarum 45 activates SHP2 through inhibition of oxidative stress to regulate osteoblast and osteoclast differentiation
Oats 📋 ⛔37513599Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats
Phytoestrogens 📋 ⛔38140273Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density-A Systematic and Critical Review
Pomegranate Seed extract 📋 ⛔35348947Amelioration of oxidative stress, cholinergic dysfunction, and neuroinflammation in scopolamine-induced amnesic rats fed with pomegranate seed
Sesamin 📋✍ 38002386Anti-COVID-19, Anti-Inflammatory, and Anti-Osteoarthritis Activities of Sesamin from Sesamum indicum L
Tomato 📋 ⛔38016800Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice
Vegetables 📋 38125727Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice
Andrographis 📋✍⛔38057817Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway
Apple Polyphenols 📋 ⛔36358458Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars
Dairy 📋 38726444The relationship between fermented and nonfermented dairy products consumption and hypertension among premature coronary artery disease patients: Iran premature coronary artery disease study
Holy Basil 📋✍⛔35900690Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels
Isoliquiritigenin 📋 36484427Isoliquiritigenin inhibits microglia-mediated neuroinflammation in models of Parkinson's disease via JNK/AKT/NFκB signaling pathway
L-Glutamine 📋✍⛔38489176Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease
Licochalcones 📋 37762479Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment
MSM 📋✍⛔36309396Effects of Methylsulfonylmethane on UVB-induced Skin Damage: An Experimental Study in a Mouse Model
Pistachio 📋✍⛔38726394Pistachio green hull and pomegranate peel extracts as two natural antiglycation agents
Royal Jelly 📋✍⛔38629388Long-term administration of royal jelly regulates age-related disorders and improves gut function in naturally aging mice
Vitamin B1 📋✍⛔38601615Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014
Arctiin 📋 37800616Arctiin attenuates iron overload‑induced osteoporosis by regulating the PI3K/Akt pathway
Bacopa Monnieri 📋✍⛔38143280Amelioration of Amyloid-β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/β-Catenin Signaling
Bilobalide 📋 36830083Radical Scavenging Potential of Ginkgolides and Bilobalide: Insight from Molecular Modeling
Boron 📋✍⛔38216793Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol
Clove 📋 ⛔37851769Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat
Clove Essential Oil 📋 ⛔37141519[Impact of essential oil vapors inhalation on blood pressure in patients with hypertension]
Copper 📋✍⛔36869998Association Between Serum Copper Levels and Urinary Incontinence in Adult Men
Cornus 📋 38111697Cornus officinalis: a potential herb for treatment of osteoporosis
Diosgenin 📋 38463710Diosgenin alleviates D-galactose-induced oxidative stress in rats' brain and liver targeting aging and apoptotic marker genes
Gardenia 📋 ⛔38000495Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome
Honey 📋✍⛔37570596Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Morin 📋 38423257Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats
Nattokinase 📋✍⛔38586318Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats
Paeonol 📋 38493906Paeonol alleviates postmenopause-induced neuropsychiatric symptoms through the modulation of GPR30 in ovariectomized mice
Quercitrin 📋 37952573Quercitrin attenuates the progression of osteoarthritis via inhibiting NF-κB signaling pathways and enhance glucose transport capacity
Sirtuin Activators 📋 38680178Role of sirtuins in epigenetic regulation and aging control
Tannic Acid 📋✍⛔37887397The Impact of Tannic Acid Consumption on Bone Mineralization
Artemisinin 📋 38056239Artemisinin protects dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in a mouse model of Parkinson's disease
Bay Leaf 📋 ⛔35631169Laurel Attenuates Dexamethasone-Induced Skeletal Muscle Atrophy In Vitro and in a Rat Model
Bee Venom 📋✍⛔37317907Memory Enhancing and Neurogenesis Activity of Honey Bee Venom in the Symptoms of Amnesia: Using Rats with Amnesia-like Alzheimer's Disease as a Model
Berries 📋 35010877Neurocognitive Effects of Cocoa and Red-Berries Consumption in Healthy Adults
Beta-Sitosterol 📋✍⛔38461353Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles
Black Ginger 📋✍⛔36904098Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia
Butyrate 📋 ⛔38694925Buty and the beast: the complex role of butyrate in Parkinson's disease
Coriander Essential Oil 📋✍⛔37627529Direct Evidence for Using Coriandrum sativum var. microcarpum Essential Oil to Ameliorate Scopolamine-Induced Memory Impairment and Brain Oxidative Stress in the Zebrafish Model
Cyanidin 📋✍ 38705400Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling
Equol 📋✍⛔37569440Equol and Resveratrol Improve Bone Turnover Biomarkers in Postmenopausal Women: A Clinical Trial
Flaxseed 📋✍⛔36622248Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials
Flaxseed Oil 📋✍⛔35859037The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials
Honokiol 📋 37637959Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression
Icaritin 📋 38237539Metabolomics and pharmacodynamic analysis unveil the therapeutic role of icaritin on osteoporosis rats
Jujube 📋 ⛔37569133Sleep-Enhancing Effect of Water Extract from Jujube ( Zizyphus jujuba Mill.) Seeds Fermented by Lactobacillus brevis L32
L-Tryptophan 📋✍⛔34924776Dietary Tryptophan and the Risk of Metabolic Syndrome: Total Effect and Mediation Effect of Sleep Duration
Linalool 📋 ⛔38723901Linalool acts as a chemical chaperone by inhibiting amyloid-β aggregation
Lingonberry 📋 ⛔37818259Comprehensive phytochemical analysis of lingonberry ( Vaccinium vitis-idaea L.) from different regions of China and their potential antioxidant and antiproliferative activities
Linoleic Acid 📋✍⛔37513547Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease
Liquiritin 📋 38423170Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis
Loquat 📋✍⛔30827108Ursolic Acid Isolated from the Leaves of Loquat ( Eriobotrya japonica) Inhibited Osteoclast Differentiation through Targeting Exportin 5
Maitake Mushrooms 📋 ⛔36297052Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts
Milk 📋 ⛔37558894Milk intake and hip fracture incidence in community-dwelling old Icelandic adults
Mushrooms 📋 ⛔38535223Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms
Nutmeg 📋✍⛔35662922Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease
Patchouli 📋✍⛔37177974Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras/Raf-1/ERK1/2 signalling pathway
Polydatin 📋✍ 38606875Polydatin protects against articular cartilage degeneration by regulating autophagy mediated by the AMPK/mTOR signaling pathway
Potassium 📋✍⛔38163867Effect of low sodium and high potassium diet on lowering blood pressure and cardiovascular events
Red Yeast Rice 📋✍⛔37111106Effects of Monacolin K in Nondiabetic Patients with NAFLD: A Pilot Study
Rehmannia 📋✍⛔37674829Rehmannia alcohol extract inhibits neuropeptide secretion and alleviates osteoarthritis pain through cartilage protection
Rosemary Essential Oil 📋✍⛔37141519[Impact of essential oil vapors inhalation on blood pressure in patients with hypertension]
Shiitake Mushrooms 📋✍⛔38036238Potential role of ergothioneine rich mushroom as anti-aging candidate through elimination of neuronal senescent cells
Thyme Essential Oil 📋 ⛔38688382Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Trans-Resveratrol 📋 34402024Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial
Vitamin B2 📋✍⛔38549750Association of vitamins B1 and B2 intake with early-onset sarcopenia in the general adult population of the US: a cross-sectional study of NHANES data from 2011 to 2018
Vitamin K1 📋✍⛔36651485Higher Dietary Vitamin K Intake is Associated with Better Physical Function and Lower Long-Term Injurious Falls Risk in Community-Dwelling Older Women
Camellia 📋 ⛔36365366Camellia japonica Root Extract Increases Antioxidant Genes by Induction of NRF2 in HeLa Cells
CAPE 📋 37313025Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease
Cardamonin 📋 38520666Cardamonin inhibits osteogenic differentiation by downregulating Wnt/beta-catenin signaling and alleviates subchondral osteosclerosis in osteoarthritic mice
Cheese 📋 ⛔38306036The Relationship Between Fermented Dairy Consumption with Cognitive Function Among Older US Adults: Data from the NHANES 2011-2014
Dioscin 📋 38024855Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling
Geraniol 📋 37118873Geraniol protects hippocampal CA1 neurons and improves functional outcomes in global model of stroke in rats
Giloy 📋✍⛔37579290Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice
Iron 📋✍⛔38693478Association between plasma metal exposure and health span in very elderly adults: a prospective cohort study with mixture statistical approach
Milk Thistle 📋✍⛔35315713Effect of Milk thistle ( Silybum marianum) supplementation on the Serum levels of oxidative stress markers in male half marathon athletes
Osmanthus 📋✍⛔38449662Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome
Phloretin 📋 38705496Phloretin Prolongs Lifespan of Caenorhabditis elegans via Inhibition of NDUFS1 and NDUFS6 at Mitochondrial Complex â… 
Safranal 📋 38683404Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation
Star Fuit 📋 ⛔35359233Star fruit extract and C-glycosylated flavonoid components have potential to prevent air pollutant-induced skin inflammation and premature aging
Stigmasterol 📋 38461353Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles
Tamarind 📋 ⛔37571339Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand-Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation
Vitamin B Complex 📋 ⛔35889778B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study
Wine 📋 ⛔38521977Is coffee, tea, and red wine consumption beneficial for individuals with hypertension?
Withanolides 📋 34925020Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect
Zingerone 📋 29117507Zingerone protects keratinocyte stem cells from UVB-induced damage
Aloin 📋 35421539Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin
Anise 📋✍⛔31724151Aqueous anise extract alleviated the pancreatic changes in streptozotocin-induced diabetic rat model via modulation of hyperglycaemia, oxidative stress, apoptosis and autophagy: a biochemical, histological and immunohistochemical study
Astragalin 📋 36681681Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice
Carnosol 📋 35593299Carnosol inhibits osteoclastogenesis in vivo and in vitro by blocking the RANKL‑induced NF‑κB signaling pathway
Conjugated Linoleic Acid 📋✍⛔36028179Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose transporter levels
Coptis Chinensis 📋 ⛔38599826Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells
Fermented Foods 📋 ⛔38292116Miso, fermented soybean paste, suppresses high-fat/high-sucrose diet-induced muscle atrophy in mice
Grapefruit 📋 ⛔36839155Chondroprotective Effects of Grapefruit ( Citrus paradisi Macfad.) Juice in a Complete Freund's Adjuvant Rat Model of Knee Osteoarthritis
Guava 📋 ⛔36271572Effects of Psidium guajava L. leaves extract on blood pressure control and IL-10 production in salt-dependent hypertensive rats
Hazelnut 📋 ⛔33802107Antioxidant and Antiglycation Effects of Polyphenol Compounds Extracted from Hazelnut Skin on Advanced Glycation End-Products (AGEs) Formation
Hops 📋✍⛔37375599Effect of a Hop Extract Standardized in 8-Prenylnaringenin on Bone Health and Gut Microbiome in Postmenopausal Women with Osteopenia: A One-Year Randomized, Double-Blind, Placebo-Controlled Trial
Horny Goat Weed 📋✍⛔38027566A literature review on Epimedium, a medicinal plant with promising slow aging properties
Indian Mulberry 📋✍⛔38264863EXPRESS: Morinda officinalis polysaccharide promotes the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells via microRNA-210-3p / scavenger receptor class A member 3
Isorhamnetin 📋 38331017Isorhamnetin suppresses the epithelial-mesenchymal transition of the retinal pigment epithelium both in vivo and in vitro through Nrf2-dependent AKT/GSK-3β pathway
Lavender 📋✍⛔38078339Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats
Lemon 📋 ⛔38016800Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice
Liquiritigenin 📋 36575875Liquiritigenin reverses skin aging by inhibiting UV-induced mitochondrial uncoupling and excessive energy consumption
Long Pepper 📋 ⛔38328576Network analysis, in vivo, and in vitro experiments identified the mechanisms by which Piper longum L. [Piperaceae] alleviates cartilage destruction, joint inflammation, and arthritic pain
Lychee 📋 ⛔35432979Effect of oligonol, a lychee-derived polyphenol, on skeletal muscle in ovariectomized rats by regulating body composition, protein turnover, and mitochondrial quality signaling
Magnolia 📋✍⛔35308213Vasorelaxant Activities and its Underlying Mechanisms of Magnolia Volatile Oil on Rat Thoracic Aorta Based on Network Pharmacology
Magnolol 📋 38326350Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance
Malvidin 📋 35874261Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property
Mandarin 📋 35529692Antioxidant activities of premature and mature mandarin ( Citrus unshiu) peel and juice extracts
Neferine 📋 37921051Neferine exerts anti‑inflammatory activity in BV‑2 microglial cells and protects mice with MPTP‑induced Parkinson's disease by inhibiting NF‑κB activation
Nitrate 📋✍⛔38403254Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials
Oolong Tea 📋 ⛔35629970Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice
Peppermint Essential Oil 📋✍⛔37743153The effect of aromatherapy massage with lemon and peppermint essential oil on menopausal symptoms: A double-blinded, randomized placebo controlled clinical trial
Progesterone 📋✍⛔36967764Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7)
Pumpkin Seed Oil 📋✍⛔34451628Evaluation of Fatty Acid Compositions, Antioxidant, and Pharmacological Activities of Pumpkin ( Cucurbita moschata) Seed Oil from Aqueous Enzymatic Extraction
Soy Protein 📋✍⛔38174000Protein supplementation: the double-edged sword
Theobromine 📋✍⛔36997493Correlation between dietary theobromine intake and low cognitive performance in older adults in the United States: A cross-sectional study based on the National Health and Nutrition Examination Survey
Vitex 📋✍⛔36075867Anticholinergic, antioxidant, and antibacterial properties of Vitex agnus-castus L. seed extract : Assessment of its phenolic content by LC-MS/MS
Withaferin A 📋 34204308Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives
Amaranth 📋 ⛔35796287Multigrain porridge possesses superior nutritional quality, its consumption alleviates hyperglycemia, hypercholesterolemia and oxidative stress in obese-diabetic wistar rats
Anethole 📋 37972114Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats
Apple Vinegar 📋✍⛔36152934Dose-dependent effect of vinegar on blood pressure: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials
Asafoetida 📋✍⛔36857494Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease
Betulinic Acid 📋 38337725Betulinic Acid Increases the Lifespan of Drosophila melanogaster via Sir2 and FoxO Activation
Biochanin A 📋 36379122Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis
Boric Acid 📋✍⛔38216793Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol
Chaga Mushrooms 📋✍⛔38053824Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system
Egg 📋 ⛔38696440Egg consumption and bone mass density among the elderly: A scoping review
Geraniin 📋 37375598Geraniin Ameliorates Hypertensive Vascular Remodelling in a Diet-Induced Obese Animal Model through Antioxidant and Anti-Inflammatory Effects
Glutathione 📋✍⛔38673745The Role of Glutathione in Age-Related Macular Degeneration (AMD)
Lemon Essential Oil 📋✍⛔37743153The effect of aromatherapy massage with lemon and peppermint essential oil on menopausal symptoms: A double-blinded, randomized placebo controlled clinical trial
Lemon Verbena 📋 ⛔35011093Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract
Myrtle 📋✍⛔34845586Ethanol Extract of Myrtle (Myrtus communis L.) Berries as a Remedy for Streptozotocin-Induced Oxidative Stress in Rats
Neohesperidin 📋 38226659Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice
Nootkatone 📋 38001852Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model
Oleanolic Acid 📋 38471277Oleanolic acid exerts bone anabolic effects via activation of osteoblastic 25-hydroxyvitamin D 1-alpha hydroxylase
Oyster 📋 ⛔36547896Purification and Identification of Peptides from Oyster ( Crassostrea hongkongensis) Protein Enzymatic Hydrolysates and Their Anti-Skin Photoaging Effects on UVB-Irradiated HaCaT Cells
Papaya 📋✍⛔37842248Unripe Carica papaya Fresh Fruit Extract Protects against Methylglyoxal-Mediated Aging in Human Dermal Skin Fibroblasts
Peppermint 📋✍⛔38625964Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities
Perilla 📋✍ 36637040Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial
Pu-erh Tea 📋✍⛔31849675Pu-Erh Tea Relaxes the Thoracic Aorta of Rats by Reducing Intracellular Calcium
Pyridoxal-5-Phosphate 📋✍⛔35678366Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K
Rhodiola 📋✍⛔37569669Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases
Sesame 📋✍⛔37539928Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells
Spices 📋 35185215Antioxidant, antimicrobial and DNA damage protecting potential of hot taste spices: a comparative approach to validate their utilization as functional foods
Stevia 📋✍⛔37836640Unlocking the Therapeutic Potential of Stevia rebaudiana Bertoni: A Natural Antiglycating Agent and Non-Toxic Support for HDF Cell Health
Sweet Potato 📋 ⛔35720655Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction
Syringic Acid 📋 38616762Syringic Acid Attenuates the IL-1β-Induced Akt Pathway in Chondrocyte ATDC5 Cells
Yogurt 📋 ⛔38306036The Relationship Between Fermented Dairy Consumption with Cognitive Function Among Older US Adults: Data from the NHANES 2011-2014
Alpha GPC 📋✍⛔38595916Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease
Amino Acids 📋 34420200Effect of Vitamin-Containing Amino Acid Supplements on Menopausal Symptoms and Age-Related Skin Changes: A Randomised, Double-Blind, Placebo-Controlled Study
Anthocyanidins 📋 35889793The Potential Roles of Dietary Anthocyanins in Inhibiting Vascular Endothelial Cell Senescence and Preventing Cardiovascular Diseases
Ashitaba 📋✍⛔38390941Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice
Basil Essential Oil 📋✍⛔37141519[Impact of essential oil vapors inhalation on blood pressure in patients with hypertension]
Beta-Alanine 📋✍⛔38243982The Possible Roles of β-alanine and L-carnosine in Anti-aging
Bitter Orange 📋✍⛔38078339Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats
Captopril 📋 37735515Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice
Celery 📋 ⛔38505582Antihypertensive Property of Celery: A Narrative Review on Current Knowledge
Chamomile Essential Oil 📋✍⛔38229887Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease
Cinnamon Essential Oil 📋✍⛔33679180Renoprotective effects of cinnamon oil against APAP-Induced nephrotoxicity by ameliorating oxidative stress, apoptosis and inflammation in rats
Citrus Fruits 📋 ⛔36156675The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial
Cryptotanshinone 📋 36386220Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis
DMAE 📋✍⛔25133239Effects of dimethylaminoethanol and compound amino acid on D-galactose induced skin aging model of rat
Eucalyptol 📋 37886137Effect of eucalyptol on matrix metalloproteinase-9 and its tissue inhibitor in hypertensive rats
Grapefruit extract 📋✍⛔30115889Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats
Guggulsterone 📋 35889266Antiaging Mechanism of Natural Compounds: Effects on Autophagy and Oxidative Stress
Isoquercitrin 📋 38337181Protective effect of isoquercitrin on UVB-induced injury in HaCaT cells and mice skin through anti-inflammatory, antioxidant, and regulation of MAPK and JAK2-STAT3 pathways
L-Lysine 📋✍⛔38639736Lysine and salt-sensitive hypertension
Laminaria 📋✍⛔36084871Antioxidant and anti-aging activities of Laminaria japonica polysaccharide in Caenorhabditis elegans based on metabonomic analysis
Lemongrass 📋✍⛔36290288Exploring the Anti-Hypertensive Potential of Lemongrass-A Comprehensive Review
Maca Root 📋✍⛔38340399Macamide, a component of maca (Lepidium meyenii Walp) lipophilic extract, enhances myogenic differentiation via AKT/p38 signaling and attenuates dexamethasone-induced muscle atrophy
Madecassoside 📋 37976111Synergistic Effect of Madecassoside and Rosmarinic Acid Against Ultraviolet B-Induced Photoaging in Human Skin Fibroblasts
Mango 📋 ⛔35565960A New Xanthone Glycoside from Mangifera indica L.: Physicochemical Properties and In Vitro Anti-Skin Aging Activities
Minerals 📋 38244989Effect of multivitamin-mineral supplementation versus placebo on cognitive function: Results from the clinic sub-cohort of the COSMOS randomized clinical trial and meta-analysis of three cognitive studies within COSMOS
Morusin 📋 37807416Morusin Inhibits RANKL-induced Osteoclastogenesis and Ovariectomized Osteoporosis
Oregano Essential Oil 📋✍⛔35201555A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
Peanut 📋 ⛔34747100Flavonoid-like Components of Peanut Stem and Leaf Extract Promote Sleep by Decreasing Neuronal Excitability
Pear 📋 ⛔38010847Unripe Pear Extract Suppresses UVB-Induced Skin Photoaging in Hairless Mice and Keratinocytes
Pelargonidin 📋 37315775Pelargonidin ameliorates inflammatory response and cartilage degeneration in osteoarthritis via suppressing the NF-κB pathway
Red Clover 📋✍⛔35204317The Effect of Traditional and Cyclodextrin-Assisted Extraction Methods on Trifolium pratense L. (Red Clover) Extracts Antioxidant Potential
Rosehip 📋✍⛔37110778Bioactive Compounds and Antioxidant Activity in the Fruit of Rosehip ( Rosa canina L. and Rosa rubiginosa L.)
Safflower 📋✍⛔35940347Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model
Sesame Oil 📋 ⛔38172141Daily supplement of sesame oil prevents postmenopausal osteoporosis via maintaining serum estrogen and aromatase levels in rats
Vitexin 📋 37102042Beneficial Role of Vitexin in Parkinson's Disease
Artichoke 📋✍⛔35949557Anti-hypertensive Effects of Artichoke Supplementation in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials
Asparagus 📋 ⛔35021947Antiglycation activity of β- glucogallin from Asparagus racemosus
Avocado Oil 📋 ⛔34832999Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress
Balloon Flower 📋✍⛔38312605A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways
Bamboo 📋✍⛔38334213The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model
Bergamot Essential Oil 📋✍⛔38490827The effect of lavender and bergamot oil applied via inhalation on the anxiety level and sleep quality of surgical intensive care unit patients
Beta-Glucan 📋✍⛔37513599Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats
Bitter Melon 📋✍⛔36902074The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease
Black Tea Polyphenols 📋 37781120Ameliorative effect of black tea extract on the skin of D-galactose-induced aging mice
Broccoli 📋 ⛔37821474Potential chemopreventive effects of Broccoli extract supplementation against 7, 12 dimethyl Benz(a)anthracene (DMBA) -induced toxicity in female rats
Casein Protein 📋✍⛔36235859Effect of Casein Hydrolysate on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Chicoric Acid 📋 38542381Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models
Cinnamic Acid 📋 35114540Cinnamic acid derivatives linked to arylpiperazines as novel potent inhibitors of tyrosinase activity and melanin synthesis
Corn Silk 📋✍⛔38226236A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile
Coumaric acid 📋 37414223p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model
Cucumber 📋 ⛔38162466Cucumber ( Cucumis sativus L.) Fruit and Combination with Losartan Attenuate the Elevation of Blood Pressure in Hypertensive Rats Induced by Angiotensin II
Eggplant 📋 ⛔36985807Evaluation of the Antihypertensive Activity of Eggplant Acetylcholine and γ-Aminobutyric Acid in Spontaneously Hypertensive Rats
Eleuthero 📋✍⛔38545117Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway
Escin 📋✍⛔34666284Beneficial effects of β-escin on muscle regeneration in rat model of skeletal muscle injury
Forskolin 📋✍⛔36926021A standardized extract of Coleus forskohlii root protects rats from ovariectomy-induced loss of bone mass and strength, and impaired bone material by osteogenic and anti-resorptive mechanisms
Genipin 📋 37865990Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease
Geranium Essential Oil 📋 ⛔34552986Topical Delivery of Geranium/Calendula Essential Oil-Entrapped Ethanolic Lipid Vesicular Cream to Combat Skin Aging
Ginger Essential Oil 📋✍ 31144450Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis
Glabridin 📋 38497297Effect of glabridin combined with bakuchiol on UVB-induced skin damage and its underlying mechanism: An experimental study
Helichrysum 📋 ⛔35761653Edible flowers of Helichrysum italicum: Composition, nutritive value, and bioactivities
Honeysuckle 📋 ⛔35495054Lonicerae Japonicae Flos Extract Promotes Sleep in Sleep-Deprived and Lipopolysaccharide-Challenged Mice
Horsetail Grass 📋✍⛔38574619Equisetum arvense standardized dried extract hinders age-related osteosarcopenia
Inulin 📋✍⛔38282163Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders
L-Histidine 📋✍⛔35429681Oral histidine intake improves working memory through the activation of histaminergic nervous system in mice
L-Threonine 📋✍⛔36323683L-threonine promotes healthspan by expediting ferritin-dependent ferroptosis inhibition in C. elegans
Lauric Acid 📋✍ 35360165Dual Roles of Coconut Oil and Its Major Component Lauric Acid on Redox Nexus: Focus on Cytoprotection and Cancer Cell Death
Mango Leaf 📋 ⛔33167456Metabolomic Profiling of Mango ( Mangifera indica Linn) Leaf Extract and Its Intestinal Protective Effect and Antioxidant Activity in Different Biological Models
Marigold 📋✍⛔38268908Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease
Myrrh 📋✍⛔36015092The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy
Oleic Acid 📋 ⛔35159328Lifespan Increase of Podospora anserina by Oleic Acid Is Linked to Alterations in Energy Metabolism, Membrane Trafficking and Autophagy
PEA 📋✍⛔34658885Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer's Disease
Postbiotics 📋 38462039Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms
Prunella Vulgaris 📋✍⛔37640280An aqueous extract of Prunella vulgaris L. ameliorates cadmium-induced bone loss by promoting osteogenic differentiation in female rats
Pumpkin Seed 📋✍⛔38397839Evaluation of Antioxidant Effects of Pumpkin ( Cucurbita pepo L.) Seed Extract on Aging- and Menopause-Related Diseases Using Saos-2 Cells and Ovariectomized Rats
Quinoa 📋 ⛔38284744Quinoa alleviates osteoporosis in ovariectomized rats by regulating gut microbiota imbalance
Rice 📋 ⛔37375622Rice Germ Attenuates Chronic Unpredictable Mild Stress-Induced Muscle Atrophy
Rosavin 📋 ⛔38277040Rosavin extends lifespan via the insulin/IGF-1 signaling pathway in Caenorhabditis elegans
SAMe 📋✍⛔38489960Plasma metabolomics identifies S-adenosylmethionine as a biomarker and potential therapeutic target for vascular aging in older adult males
Scutellarin 📋 36271561Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction
Sea Cucumber 📋 38369274Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification
Seafood 📋 38706279Fish and Shellfish Consumption, Cognitive Health and Mortality from Alzheimer's Disease among US Adults Aged 60 and Older
Sesamol 📋 37333469Neuroprotective effects of sesamol against LPS-induced spatial learning and memory deficits are mediated via anti-inflammatory and antioxidant activities in the rat brain
Shogaol 📋 373378306-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model
Spinach 📋 ⛔37033738Spinach ( Spinacia oleracea) microgreen prevents the formation of advanced glycation end products in model systems and breads
Turkey Tail Mushrooms 📋 ⛔36289766Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice
Yerba Mate 📋✍⛔36647770Physiological effects of yerba maté (Ilex paraguariensis): a systematic review
Apricot 📋 ⛔36212969Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model
Arachidonic Acid 📋✍⛔38710468Arachidonic acid in aging: New roles for old players
Arnica 📋✍⛔35795190Anti-oxidant Effect of High Dilutions of Arnica montana, Arsenicum Album, and Lachesis Mutus in Microglial Cells in Vitro
Atractylodes 📋✍⛔37268258Potential application of Atractylodes macrocephala Koidz. as a natural drug for bone mass regulation: A review
Barley 📋✍⛔36538519Highland Barley Tea Polyphenols Extract Alleviates Skeletal Muscle Fibrosis in Mice by Reducing Oxidative Stress, Inflammation, and Cell Senescence
Bee Pollen 📋✍⛔33430511Antioxidant Activity in Bee Products: A Review
Buckwheat 📋 ⛔35807886Buckwheat Flour and Its Starch Prevent Age-Related Cognitive Decline by Increasing Hippocampal BDNF Production in Senescence-Accelerated Mouse Prone 8 Mice
Cabbage 📋 ⛔37781995Red Cabbage Anthocyanins Attenuate Cognitive Impairment By Attenuating Neuroinflammation and Regulating Gut Microbiota in Aging Mice
Carrot 📋 ⛔26644239Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies
Cashew 📋 ⛔36578402Antihypertensive activity of roasted cashew nut in mixed petroleum fractions-induced hypertension: An in vivo and in silico approaches
Corn 📋 ⛔35485907Black corn ( Zea mays L.) whole flour improved the antioxidant capacity and prevented adipogenesis in mice fed a high-fat diet
Costus 📋✍⛔33689077Preventive Effect of Saussurea lappa Extract on Osteoarthritis in Mice Model through Inhibition of NF-κB Pathway
D-Mannose 📋✍⛔38101412D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder
Diallyl Trisulfide 📋 38185348Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210
Dihydroartemisinin 📋 38439187Dihydroartemisinin eliminates senescent cells by promoting autophagy-dependent ferroptosis via AMPK/mTOR signaling pathway
Dill 📋 ⛔37836586Anti-Osteoporotic Potential of Water Extract of Anethum graveolens L. Seeds
Essential Fatty Acids 📋✍ 33692241Fatty Acids and Lipid Derivatives Protecting Photooxidative Attack in Age-related Macular Degeneration
Eucalyptus 📋✍⛔35335937Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of Eucalyptus globulus Leaves
Fat 📋 38036572A prospective cohort study on the association between dietary fatty acids intake and risk of hypertension incident
Fennel Essential Oil 📋✍⛔36559685Antimicrobial, Antibiofilm, and Antioxidant Properties of Essential Oil of Foeniculum vulgare Mill. Leaves
Flavones 📋 38630898The association between flavonoids intake and hypertension in U.S. adults: A cross-sectional study from The National Health and Nutrition Examination Survey
Gamma-Linolenic Acid 📋✍⛔35740923Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study
Ginkgetin 📋 33204684Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway
Glycolic Acid 📋✍⛔33458927Effect of Glycolic Acid, Phytic Acid, Soothing Complex Containing Emulsion on Hyperpigmentation and Skin Luminosity: A Clinical Evaluation
Grape Seed Oil 📋 ⛔32912277The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models
Horse Chestnut 📋✍⛔35408675Red Horse Chestnut and Horse Chestnut Flowers and Leaves: A Potential and Powerful Source of Polyphenols with High Antioxidant Capacity
Iodine 📋✍⛔36558407Protection of Vitamin C on Oxidative Damage Caused by Long-Term Excess Iodine Exposure in Wistar Rats
Jasmine 📋 ⛔35685730Integrating In Silico and In Vitro Approaches to Screen the Antidiabetic Properties from Tabernaemontana divaricata (Jasmine) Flowers
Knotweed 📋✍⛔37016525The possibility of Polygonum cuspidatum Against Osteoarthritis Based on Network Pharmacology and Molecular Docking
L-Alanine 📋✍⛔38096603Oral glutamine supplementation relieves muscle loss in immobilized rats, altering p38MAPK and FOXO3a signaling pathways
Lecithin 📋✍⛔34603603Combined effects of soy isoflavone and lecithin on bone loss in ovariectomized mice
Lettuce 📋 ⛔35889834Evaluation of the Effectiveness of Fermented Soybean-Lettuce Powder for Improving Menopausal Symptoms
Limonin 📋 37536186Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats
Matcha Tea 📋 33256220Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals
Mint 📋 ⛔37416794AGEs Blockerâ„¢ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice
Mucuna Pruriens 📋✍⛔36458299Hypolipidemic and antioxidant effects of vegetal milk produced with Mucuna pruriens L. seed in rats fed a high-fat diet
MUFA 📋 ⛔38535988Relationship between fatty acid intake and aging: a Mendelian randomization study
Neroli Essential Oil 📋✍⛔35855386The Impact of Aromatherapy with Citrus Aurantium Essential Oil on Sleep Quality in Pregnant Women with Sleep Disorders: A Randomized Controlled Clinical Trial
Olive 📋✍⛔36861461Dietary intake of table olives exerts antihypertensive effects in association with changes in gut microbiota in spontaneously hypertensive rats
Oregano 📋✍⛔33424252The impact of different extracts of six Lamiaceae species on deleterious effects of oxidative stress assessed in acellular, prokaryotic and eukaryotic models in vitro
Oyster Mushrooms 📋 ⛔36144225Elemental Analysis, Phytochemical Screening and Evaluation of Antioxidant, Antibacterial and Anticancer Activity of Pleurotus ostreatus through In Vitro and In Silico Approaches
Phosphatidylcholine 📋✍⛔36363476Protective Effects of Phosphatidylcholine against Hepatic and Renal Cell Injury from Advanced Glycation End Products
Phosphatidylserine 📋✍⛔35866081A Dietary Supplement Containing Micronutrients, Phosphatidylserine, and Docosahexaenoic Acid Counteracts Cognitive Impairment in D-Galactose-Induced Aged Rats
Phytosterols 📋 38327787Cholesterol-metabolism, plant sterols, and long-term cognitive decline in older people - Effects of sex and APOEe4
Piperlongumine 📋 38311970Piperlongumine, a Piper longum-derived amide alkaloid, protects mice from ovariectomy-induced osteoporosis by inhibiting osteoclastogenesis via suppression of p38 and JNK signaling
Pomelo 📋 ⛔34651409Evaluation of pomelo seed extracts as natural antioxidant, antibacterial, herbicidal agents, and their functional components
Poria Mushrooms 📋✍ 37836526Efficacy of Poria Cocos Extract on Sleep Quality Enhancement: A Clinical Perspective with Implications for Functional Foods
Potato 📋 ⛔35223568The Relationship between Dietary Patterns and Bone Mineral Density of 476 Middle-Aged and Aged People
Pregnenolone 📋✍⛔36878398Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease
Proanthocyanidins 📋 36290623Anti-Aging Effect and Mechanism of Proanthocyanidins Extracted from Sea buckthorn on Hydrogen Peroxide-Induced Aging Human Skin Fibroblasts
Pumpkin 📋 ⛔37398913Evaluation of Antidiabetic and Antioxidant Activities of Fruit Pulp Extracts of Cucurbita moschata Duchesne and Cucurbita maxima Duchesne
Rapeseed Oil 📋✍ 35596008The effects of sesame, canola, and sesame-canola oils on cardiometabolic markers in patients with type 2 diabetes: a triple-blind three-way randomized crossover clinical trial
Salt 📋 ⛔36028560The association between dietary sodium intake and osteoporosis
Saw Palmetto 📋✍⛔34161166Standardized Saw Palmetto Extract Directly and Indirectly Affects Testosterone Biosynthesis and Spermatogenesis
Scutellarein 📋 38695125Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies
Shea 📋 ⛔33364595Hypoglycemic, antidyslipidemic and antioxydant effects of Vitellaria paradoxa barks extract on high-fat diet and streptozotocin-induced type 2 diabetes rats
Shilajit 📋✍⛔37513872Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer's Disease
Soybean Oil 📋 ⛔37461334Effect of lard plus soybean oil on blood pressure and other cardiometabolic risk factors in healthy subjects: a randomized controlled-feeding trial
Spearmint 📋 ⛔29314866Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment
Spearmint Essential Oil 📋✍⛔34201645Mint Oils: In Vitro Ability to Perform Anti-Inflammatory, Antioxidant, and Antimicrobial Activities and to Enhance Intestinal Barrier Integrity
Star Anise 📋✍⛔37971467Protective Effect of Illicium Verum Extract On Vascularization In Rats With Osteoporotic Fracture
Tangerine 📋 ⛔35100035Effects of Citrus depressa Hayata Fruit Extract on Thigh Muscles Mass and Composition in Subacute Stroke Patients: A Double-Blind, Randomized, Controlled Pilot Trial
Terpenoids 📋 35651977Evolving Roles of Natural Terpenoids From Traditional Chinese Medicine in the Treatment of Osteoporosis
UDCA 📋✍⛔38024855Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling
Vitamin B5 📋✍⛔32416962Cerebral Deficiency of Vitamin B5 (D-Pantothenic Acid; Pantothenate) as a Potentially-Reversible Cause of Neurodegeneration and Dementia in Sporadic Alzheimer's Disease
Vitamin B8 📋✍⛔38674244Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study
Wasabi 📋 ⛔36360048Wasabi ( Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats
White Fungus 📋 37458972Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2
White Mushrooms 📋 ⛔36291298White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease
Wood Ear Mushrooms 📋 ⛔38423908Potential inhibitory effect of Auricularia auricula polysaccharide on advanced glycation end-products (AGEs)
Yiang Yiang Essential Oil 📋 ⛔38087747Effect of Lavandula angustifolia and Cananga odorata on decrease of blood pressure in high blood pressure volunteers: A randomized controlled trial
Amygdalin 📋✍⛔32794256Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay
Arjuna 📋✍⛔34798688Anti-osteoporotic effect of Terminalia arjuna (Roxb.) Wight & Arn. In bilateral ovariectomized induced post-menopausal osteoporosis in experimental rats
Banana 📋 ⛔37655002Antioxidant and anti-atherosclerotic potential of Banana ( Musa spp): A review of biological mechanisms for prevention and protection against atherosclerosis
Beer 📋 37402233Effect of moderate beer consumption (with and without ethanol) on cardiovascular health in postmenopausal women
Beta-Lapachone 📋 30739428Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
Bread 📋 36366944The impact of low-salt bread as a simple diet on hypertensive patients with cardiovascular comorbidities
Carbohydrates 📋 36539697Association of low-carbohydrate-diet score and cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES)
Cedarwood Essential Oil 📋✍⛔36978825Synergistic Antioxidant Activity of Four-Component Mixture of Essential Oils: Basil, Cedarwood, Citronella and Thyme for the Use as Medicinal and Food Ingredient
Chicory 📋✍⛔36219736Effects of Chicory and Fumitory on Hot Flashes Among Breast Cancer Survivors: A Randomized, Double-Blind Placebo-Controlled Trial
Chromium 📋✍⛔34237387Effects of chromium supplementation on blood pressure, body mass index, liver function enzymes and malondialdehyde in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of randomized controlled trials
Clary Sage Essential Oil 📋✍⛔37141519[Impact of essential oil vapors inhalation on blood pressure in patients with hypertension]
D-Limonene 📋✍⛔37189712In Vitro Screening Studies on Eight Commercial Essential Oils-Derived Compounds to Identify Promising Natural Agents for the Prevention of Osteoporosis
Delphinidin 📋 35484873Antioxidant activity of delphinidin and pelargonidin: Theory and practice
Diallyl Sulfide 📋 36052584[The protective effects of diallyl sulfide (DAS) on genotoxicity induced by benzene]
Docosapentaenoic Acid 📋✍ 35166302Twelve Weeks of Additional Fish Intake Improves the Cognition of Cognitively Intact, Resource-Limited Elderly People: A Randomized Control Trial
Eclipta Alba 📋✍ 34627325A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model
Elastin 📋✍ 38481080Oral consumption of Bonito fish-derived elastin peptide (VGPG Elastin® ) improves biophysical properties in aging skin: A randomized, double-blinded, placebo-controlled study
Emu Oil 📋✍⛔27924292Data on melanin production in B16F1 melanoma cells in the presence of emu oil
Eucalyptus Essential Oil 📋 ⛔292853091,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor
Geranium 📋 37819493Therapeutic Effects of Geranium Oil in MPTP-Induced Parkinsonian Mouse Model
Ginkgolic Acid 📋 31654699Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates
Guggul 📋✍⛔30127736Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases
Hemp Oil 📋✍⛔37704445Prophylactic Effects of Hemp Seed Oil on Perimenopausal Depression: A Role of HPA Axis
Hypericin 📋 37183545Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning
Kombucha 📋✍⛔34744740The Efficacy and Safety of Multiple Dose Regimens of Kudzu ( Pueraria lobata) Root Extract on Bone and Cartilage Turnover and Menopausal Symptoms
Marjoram 📋 ⛔38226236A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile
Mastic 📋✍⛔37796709Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of Pistacia lentiscus L., Essential Oils
Modified Citrus Pectin 📋✍⛔28858976Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive rats
Myrrh Essential Oil 📋 ⛔33421599Protective effects of Myrrh essential oil on isoproterenol-induced myocardial infarction in rats through antioxidant, anti-inflammatory, Nrf2/HO-1 and apoptotic pathways
Myrtle Essential Oil 📋✍⛔33015880Effect of myrtle (Myrtus communis L.) essential oil on oxidant-antioxidant balance in rats with propylthiouracil-induced hypothyroidism
Nimbolide 📋 38571915Nimbolide: promising agent for prevention and treatment of chronic diseases (recent update)
Nuciferine 📋 37813639Molecular docking Study of Nuciferine as a Tyrosinase Inhibitor and Its Therapeutic Potential for Hyperpigmentation
Oak Bark 📋✍⛔36145758Biological Activity of Bark Extracts from Northern Red Oak ( Quercus rubra L.): An Antioxidant, Antimicrobial and Enzymatic Inhibitory Evaluation
Okra 📋 ⛔37358589Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function
Omega-6 Fatty Acids 📋✍⛔37971997Association between the intake of dietary n3 and n6 fatty acids and stroke in US adults: A cross-sectional study of NHANES 2007-2018
Orange Essential Oil 📋✍⛔33838094The effects of foot massage on hemodialysis patients' sleep quality and restless leg syndrome: a comparison of lavender and sweet orange essential oil topical application
Pantethine 📋✍⛔37194410Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species
Papain 📋✍⛔34943090Herbal Preparation (Bromelain, Papain, Curcuma, Black Pepper) Enhances Mineralization and Reduces Glucocorticoid-Induced Osteoporosis in Zebrafish
Parthenolide 📋 37992573Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway
Pau d'Arco 📋✍⛔35240121Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates
Pectin 📋✍⛔38398646Therapeutic Potential of Pectin and Its Derivatives in Chronic Diseases
Pine Needle Essential Oil 📋✍⛔33655878Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus
Pine Nut 📋 ⛔37821052Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
Prickly Pear 📋 ⛔36942614Characterization and anti-aging effects of Opuntia ficus-indica (L.) Miller extracts in a D-galactose-induced skin aging model
Psyllium 📋✍⛔32066221The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials
Retinoic Acid 📋 38002296Human Skin Aging and the Anti-Aging Properties of Retinol
Rose 📋 37078068Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study
Rose Essential Oil 📋 38688895A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats
Rye 📋 ⛔34439463Unraveling the Bioactive Profile, Antioxidant and DNA Damage Protection Potential of Rye ( Secale cereale) Flour
Salicylic Acid 📋✍⛔34480884Salicylic acid in ginseng root alleviates skin hyperpigmentation disorders by inhibiting melanogenesis and melanosome transport
Seaweeds 📋 ⛔38029400A Combination Study of Pre- and Clinical Trial: Seaweed Consumption Reduces Aging-Associated Muscle Loss!
Serrapeptase 📋✍⛔35694981The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach
Sugarcane 📋 ⛔34209483Antioxidant and Neuroprotective Properties of Non-Centrifugal Cane Sugar and Other Sugarcane Derivatives in an In Vitro Induced Parkinson's Model
Tea Polysaccharides 📋 26130565Combination of Selenium-Enriched Green Tea Polysaccharides and Huo-ji Polysaccharides Synergistically Enhances Antioxidant and Immune Activity in Mice
Tea Tree Essential Oil 📋 ⛔35214891Chemical and Biological Characterization of Melaleuca alternifolia Essential Oil
Vitamin B7 📋✍⛔38045419Biotin rescues manganese-induced Parkinson's disease phenotypes and neurotoxicity
Water Chestnut 📋✍⛔35687659Effects of water chestnut ( Tarpa bispinosa Roxb.) extract/lutein on fingertip-measured advanced glycation endproduct/carotenoid levels
Wheat 📋 ⛔38190487Protective Effect of Whole Wheat on Muscle Atrophy in C2C12 Cells via Akt/FoxO1 Signaling Pathways
Witch Hazel 📋✍⛔30052192Understanding Solar Skin Elastosis-Cause and Treatment
Alfalfa 📋 ⛔32193946Effect of Medicago sativa compared To 17β-oestradiol on osteoporosis in ovariectomized mice
Almond Oil 📋 ⛔17348990Effect of pre-treatment of almond oil on ultraviolet B-induced cutaneous photoaging in mice
Aloe-Emodin 📋 25453793Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and Hâ‚‚Oâ‚‚-induced cytotoxicity in PC12 cells
Aloesin 📋 26265996Aloesin as a Medical Food Ingredient for Systemic Oxidative Stress of Diabetes
Apricot Kernels 📋✍⛔32794256Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay
Azadirachtin 📋 38001854Azadirachtin Attenuates Carcinogen Benzo(a) Pyrene-Induced DNA Damage, Cell Cycle Arrest, Apoptosis, Inflammatory, Metabolic, and Oxidative Stress in HepG2 Cells
Bergamottin 📋 35188515Bergamottin promotes osteoblast differentiation and bone formation via activating the Wnt/β-catenin signaling pathway
Bile Salts 📋 38680685The role of bile acids in human aging
Black Pepper Essential Oil 📋 ⛔25642050The effect of olfactory stimuli on the balance ability of stroke patients
Bladderwrack 📋✍⛔35323492The Biochemical Composition and Antioxidant Properties of Fucus vesiculosus from the Arctic Region
Bok Choy 📋 ⛔36249822Antihypertensive potential of Brassica rapa leaves: An in vitro and in silico approach
Brussels Sprouts 📋 ⛔18293303Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: results of a controlled human intervention trial
Camphor 📋✍⛔33084110Modulation of the antioxidant defense system in liver, kidney, and pancreas tissues of alloxan-induced diabetic rats by camphor
Caraway Essential Oil 📋 ⛔20608729Antioxidant and hepatoprotective potential of essential oils of coriander (Coriandrum sativum L.) and caraway (Carum carvi L.) (Apiaceae)
Castor Oil 📋✍⛔35865958Castor Oil Plant ( Ricinus communis L.) Leaves Improve Dexamethasone-Induced Muscle Atrophy via Nrf2 Activation
Catalase 📋✍⛔37879214Combination of curcumin and catalase protects against chondrocyte injury and knee osteoarthritis progression by suppressing oxidative stress
Chebulinic Acid 📋 37453379Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses
Chitosan 📋✍⛔33291821Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model
Citronella Essential Oil 📋✍⛔36978825Synergistic Antioxidant Activity of Four-Component Mixture of Essential Oils: Basil, Cedarwood, Citronella and Thyme for the Use as Medicinal and Food Ingredient
Cumin 📋 ⛔34328087Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats
D-Ribose 📋✍⛔17604325Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats
Daisy 📋 ⛔34175580Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects
Deodar Cedar 📋 22757704Chemical composition, antioxidant, and antimicrobial activities of essential oil from pine needle (Cedrus deodara)
DIM 📋✍⛔364388023,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy
Durian 📋 ⛔35186500Antioxidant and anti-inflammatory activities of durian ( Durio zibethinus Murr.) pulp, seed and peel flour
Fir Needle Oil 📋 ⛔19430614Radical Scavenging Activity of the Essential Oil of Silver Fir (Abies alba)
Fluted Gourd 📋 33402930Pumpkin seed oil alleviates oxidative stress and liver damage induced by sodium nitrate in adult rats: biochemical and histological approach
Fufang Danshen 📋 29770796Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease
Garlic Oil 📋 ⛔36364887Perinatal Garlic Oil Supplementation Averts Rat Offspring Hypertension Programmed by Maternal Chronic Kidney Disease
Glycerin 📋✍⛔36973988Reduction of wrinkles: From a computational hypothesis to a clinical, instrumental, and biological proof
Glycyrrhetinic Acid 📋 3743649118β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype
Haskap 📋 34679767Anti-Sarcopenic Obesity Effects of Lonicera caerulea Extract in High-Fat Diet-Fed Mice
L-Methionine 📋✍⛔34573099L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease
Lemon Balm Essential Oil 📋✍⛔15113145Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil
Lupeol 📋 37447385A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer's Disease
Mandarin Essential Oil 📋 ⛔36501374Citrus reticulata Leaves Essential Oil as an Antiaging Agent: A Comparative Study between Different Cultivars and Correlation with Their Chemical Compositions
Manganese 📋✍⛔37984743Manganese and sleep outcomes in US adults: results from the 2017-2020 NHANES
Marjoram Essential Oil 📋 ⛔32121614Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region
Metoprolol 📋✍⛔34800264Metoprolol Protects Against Arginine Vasopressin-Induced Cellular Senescence in H9C2 Cardiomyocytes by Regulating the Sirt1/p53/p21 Axis
Mustard 📋 ⛔34856751Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals
Noni 📋 ⛔36118093Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice
Oak Acorn 📋✍⛔34983480Protective effects of Quercus acuta Thunb. fruit extract against UVB-induced photoaging through ERK/AP-1 signaling modulation in human keratinocytes
Omega-9 Fatty Acids 📋 35956341Omega-9 Modifies Viscoelasticity and Augments Bone Strength and Architecture in a High-Fat Diet-Fed Murine Model
Parsley 📋 ⛔27255519Antiosteoporotic effect of Petroselinum crispum, Ocimum basilicum and Cichorium intybus L. in glucocorticoid-induced osteoporosis in rats
Parsnip 📋 ⛔32700246Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study
Peach 📋 ⛔29399294Topical or oral treatment of peach flower extract attenuates UV-induced epidermal thickening, matrix metalloproteinase-13 expression and pro-inflammatory cytokine production in hairless mice skin
Phellodendron 📋✍⛔33335246Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells
Pineapple 📋✍⛔25699088Antioxidant effects of pineapple vinegar in reversing of paracetamol-induced liver damage in mice
Pygeum Africanum 📋✍⛔35487926GC-MS and LC-TOF-MS profiles, toxicity, and macrophage-dependent in vitro anti-osteoporosis activity of Prunus africana (Hook f.) Kalkman Bark
Rhubarb 📋 ⛔37123167Investigation of the Effect of Rhubarb stalks extracts on Mice Exposed to Oxidative Stress
Sage Essential Oil 📋 ⛔34275073Bioactive phytochemicals from Salvia officinalis attenuate cadmium-induced oxidative damage and genotoxicity in rats
Sesamolin 📋 34194327Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling Pathways
Sodium Bicarbonate 📋✍⛔36528983Effects of sodium bicarbonate bath on the quality of sleep: An assessor-blinded, randomized, controlled, pilot clinical trial
Sorghum 📋 ⛔34690742Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article
St. Johns Wort Oil 📋 ⛔38242739The Effect of St. John's Wort Oil (Hypericum Perforatum L.) in Knee Osteoarthritis: A Randomized Controlled and Qualitative Study
Sunflower 📋 ⛔37727996Protective effect of Helianthus annuus seed byproduct extract on ultraviolet radiation-induced injury in skin cells
Theabrownins 📋 30119205Theabrownin suppresses in vitro osteoclastogenesis and prevents bone loss in ovariectomized rats
Toothache Plant 📋 32368129The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger ( Zingiber officinale) and Acmella oleracea Extracts for the Treatment of Pain and Inflammation in a Group of Subjects With Moderate Knee Osteoarthritis
Watermelon 📋 ⛔37369281Watermelon consumption decreases risk factors of cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Xylitol 📋✍⛔36154609Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice
Yohimbe 📋✍⛔36903271Yohimbine Alleviates Oxidative Stress and Suppresses Aerobic Cysteine Metabolism Elevated in the Rat Liver of High-Fat Diet-Fed Rats
Yohimbine 📋✍ 35840473Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/β-catenin and p38/MAPK signal pathways